Decoding the Roles of Long Noncoding RNAs in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. HCC is associated with several etiological factors, including HBV/HCV infections, cirrhosis, and fatty liver diseases. However, the molecular mechanism underlying HCC development remains largely elusive. The advent of high-throughput sequencing has unveiled an unprecedented discovery of a plethora of long noncoding RNAs (lncRNAs). Despite the lack of coding capacity, lncRNAs have key roles in gene regulation through interacting with various biomolecules. It is increasingly evident that the dysregulation of lncRNAs is inextricably linked to HCC cancer phenotypes, suggesting that lncRNAs are potential prognostic markers and therapeutic targets. In light of the emerging research in the study of the regulatory roles of lncRNAs in HCC, we discuss the association of lncRNAs with HCC. We link the biological processes influenced by lncRNAs to cancer hallmarks in HCC and describe the associated functional mechanisms. This review sheds light on future research directions, including the potential therapeutic applications of lncRNAs.     

Effect of different control strategies on rapid cold start-up of a 30-cell proton exchange membrane fuel cell stack

Many places experience extreme temperatures below −30 °C, which is a great challenge for the fuel cell vehicle (FCV). The aim of this study is to optimize the strategy to achieve rapid cold start-up of the 30-cell stack at different temperature conditions. The test shows that the stack rapidly starts within 30 s at an ambient temperature of −20 °C. Turning on the coolant at −25 °C show stability of the cell voltage at both ends due to the end-plate heating, however, voltage of intermediate cells fluctuates sharply, and successful start-up is completed after 60 s. The cold start strategy changes to load-voltage cooperative control mode when the ambient temperature reduced to −30 °C, the voltage of multiple cells in the middle of the stack fluctuate more drastic, and start-up takes 113 s. The performance and consistency of the stack did not decay after 20 cold start-up experiments, which indicates that our control strategies effectively avoided irreversible damage to the stack caused by freeze-thaw process.     

Fire hazard in transportation infrastructure: Review,assessment, and mitigation strategies

This paper reviews the fire problem in critical transportation infrastructures such as bridges and tunnels. The magnitude of the fire problem is illustrated, and the recent increase in fire problems in bridges and tunnels is highlighted. Recent research undertaken to address fire problems in transportation structures is reviewed, as well as critical factors governing the performance of those structures. Furthermore, key strategies recommended for mitigating fire hazards in bridges and tunnels are presented, and their applicability to practical situations is demonstrated through a practical case study. Furthermore, research needs and emerging trends for enhancing the “state-of-the-art” in this area are discussed.     

Promoting or prohibiting: Understanding the influence of social media on international students’ acculturation process,coping strategies,and psychological consequences

Although the unprecedented prevalence of social media has infiltrated into international students’ daily trajectories and become an indispensable component of their intercultural communication, yet surprisingly few attempts have been implemented to systematically unpack how the innovative technology could play a role in these sojourners’ acculturation experiences and the consequences of migration and cross-cultural adaption. In order to address such research gap, the objective of this present article is to provide a review of academic, peer-reviewed journal studies that examined the potential effect of social media engagement on international university students’ acculturation process, coping strategies, and psychological adjustments during the period from 2010 to 2019. Moreover, building upon conceptualizations from new media and transcultural research literature, a conceptual framework was developed to classify the relevant studies for further analysis. Overall, these theories and studies synthesized in this paper emphasize the vital role of social media in the acculturation, coping behaviors and mental health for ethnic minorities in the host country. Additionally, certain dimensions of attitudes and behaviors through social media could exert the important influence on the psychological adaption. Therefore, conclusions of the research may assist to further inform practitioners who may encounter newcomers’ experiencing intercultural adjustments and psychological issues in the digital media age. Furthermore, this current review may also help educators determine certain barriers that have not been resolved in campus tactics which may influence the acculturation of sojourning populations.     

Experimental Animal Model Systems for Understanding Salivary Secretory Disorders

Salivary secretory disorders are life-disrupting pathologic conditions with a high prevalence, especially in the geriatric population. Both patients and clinicians frequently feel helpless and get frustrated by the currently available therapeutic strategies, which consist mainly of palliative managements. Accordingly, to unravel the underlying mechanisms and to develop effective and curative strategies, several animal models have been developed and introduced. Experimental findings from these models have contributed to answer biological and biomedical questions. This review aims to provide various methodological considerations used for the examination of pathological fundamentals in salivary disorders using animal models and to summarize the obtained findings. The information provided in this review could provide plausible solutions for overcoming salivary disorders and also suggest purpose-specific experimental animal systems.     

MOOC study group: Facilitation strategies,influential factors,and student perceived gains

“Join a Meetup Group” (face-to-face study group) has been propagated by Coursera to build rapport and provide mutual support among MOOC learners; however, studies remain scant regarding its effectiveness and sustainability. This interpretive case study documents our facilitation process, key influential factors, as well as student perceived gains in a six-week MOOC study group. Data sources include discussion recordings, end-of-course interviews, goal setting sheets, weekly reflection journals, and researchers' observation notes. Results showed that, cognitively, participants broadened their perspective of thinking, raised cultural awareness, and shared many learning strategies. Affectively, they established a strong sense of community and gained motivation for learning. Participants also increased action tendencies toward trying out Coursera functions, new courses, and learning strategies, and they became more cognizant of the benefits and procedures of the MOOC study group. Our findings suggest that, with proper design and facilitation, face-to-face study group would be a practicable and effective approach to leverage MOOC students' motivation, engagement, and deeper learning. Implications are discussed in terms of potential gains, challenges, key influential factors, as well as future design and implementation of MOOC study groups.     

Expert system for problem solving in distance university education: The successful case of the subject “operations management”

Acquiring the skills needed to solve certain types of problems is one of the main challenges of distance university education, demanding extra motivation from students to tackle it. New technology should be one of our great allies in addressing these problems. This article proposes an expert system with a web‐based problem‐solving simulator for a multidevice environment in order to allow students to access an unlimited number of problems with their corresponding solutions, immediately, anytime and anywhere. The types of problems that can be used are those based on quantitative methods with a fixed methodology to be followed. A successful case study was carried out for the subject Operations Management at the Distance University of Madrid (UDIMA), with three different problem simulators having been developed. The results were very satisfactory compared with previous academic years in terms of motivation. A decrease in students that did not sit the final examination was observed, as was an increase in the number of visits to the Moodle classroom. Students also responded positively in their assessments of the initiative.     

面源红外诱饵对抗红外制导导弹干扰策略研究

面源红外诱饵使用的过程中,合理有效的干扰策略是干扰红外制导导弹的关键,针对这一问题,通过理论分析与仿真模拟相结合得到面源红外诱饵对抗红外制导导弹的干扰策略。首先以红外成像制导导弹为例,介绍红外制导导弹的仿真模型,然后将攻击过程分为锁定前与锁定后,以命中率为评价指标,得到两个阶段下的最佳干扰策略,包括诱饵的最佳释放时机、释放间隔以及载机应采取的机动动作等。     

新冠肺炎疫情对上海经济社会发展的影响机制与应对策略

新型冠状病毒肺炎(以下简称新冠肺炎)疫情对上海经济社会发展造成了诸多影响,上海正在深入学习贯彻习近平总书记系列重要讲话精神,坚定推进"两手抓、两手硬、两手赢"。通过电话咨询部分企业家、查阅媒体相关文献、对比SARS疫情、政策分析等方式,研究认为新冠肺炎疫情对上海经济发展的影响可以从"短期-中期-长期"的时间序列进行分析,而对社会发展影响则可从"个人-社区-城市-社会"空间序列进行探讨,在影响机制的基础上还提出了相应的对策建议。     

Complexities of digital technology use and the teaching and learning of function

Many argue that digital technologies have the potential to enhance the teaching and learning of mathematics. However, the availability of technology is not sufficient to realise this potential. The study reported takes a detailed approach to investigate the utility of the particular offerings of the available technologies in the teaching and learning of a specific area of mathematics, functions. Sixteen affordances identified in the data are described. The complexity of the process involved in resolving a situation where particular affordances would be useful so as they are perceived and enacted is detailed. Finally, a grounded theory framework arising from the data analysis from this study that can be used to explain, predict and guide action in other digital environments is presented.